Journal
CELL CYCLE
Volume 13, Issue 1, Pages 62-71Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.26755
Keywords
Cdk6; EYA2; degradation; proliferation; progenitor cell; cell cycle; cancer
Categories
Funding
- National Cancer Institute(s) of the National Institutes of Health [R15CA125731-02A1]
- National Cancer Institute(s) [R012RO1-CA095277]
- [R15GM059108-04]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1229354] Funding Source: National Science Foundation
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Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G(1) phase. Increasingly, evidence suggests that CDK6, while directly driving the cell cycle, may only be essential for proliferation of specialized cell types, agreeing with the notion that CDK6 also plays an important role in differentiation. Here, evidence is presented that CDK6 binds to and promotes degradation of the EYA2 protein. The EYA proteins are a family of proteins that activate genes essential for the development of multiple organs, regulate cell proliferation, and are misregulated in several types of cancer. This interaction suggests that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer.
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