Journal
CELL CYCLE
Volume 12, Issue 15, Pages 2371-2375Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.25380
Keywords
microRNA; miR-10b; miR-10b*; cancer; cell proliferation; therapeutic strategies
Categories
Funding
- AIRC [08/30R/89]
- Leir Charitable Foundation
Ask authors/readers for more resources
Contemporary microRNA research has led to significant advances in our understanding of the process of tumorigenesis. MicroRNAs participate in different events of a cancer cell's life, through their ability to target hundreds of putative transcripts involved in almost every cellular function, including cell cycle, apoptosis, and differentiation. The relevance of these small molecules is even more evident in light of the emerging linkage between their expression and both prognosis and clinical outcome of many types of human cancers. This identifies microRNAs as potential therapeutic modifiers of cancer phenotypes. From this perspective, we overview here the miR-10b locus and its involvement in cancer, focusing on its role in the establishment (miR-10b*) and spreading (miR-10b) of breast cancer. We conclude that targeting the locus of microRNA 10b holds great potential for cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available