Journal
CELL CYCLE
Volume 12, Issue 5, Pages 728-731Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.23949
Keywords
CIN; p53; JNK; delamination; Wingless; MMP1; stress
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Funding
- Juan de la Cierva post-doctoral contract
- Spanish Ministerio de Ciencia e Innovacion [BFU2010-21123, CSD2007-00008]
- Generalitat de Catalunya [2005 SGR 00118]
- EMBO Young Investigator Programme
- ICREA Funding Source: Custom
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Chromosomal instability (CIN) is a common feature in human cancer, and highly aneuploid tumors are frequently associated with poor prognosis; however, the molecular and cellular mechanisms underlying CIN-induced tumorigenesis are poorly understood. Here we review recent findings about the role of CIN in driving tumor-like growth and host invasiveness in Drosophila epithelia and discuss the commonalities of CIN-induced tumors with other Drosophila-based cancer models. We also discuss possible scenarios that can account for the participation of CIN in tumorigenesis and propose that, alternatively to the classical role of aneuploidy in promoting the accumulation of mutations in cancer cells, aneuploidy can be a source of stress that may contribute to cancer initiation and/or progression.
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