Journal
BLOOD
Volume 102, Issue 9, Pages 3302-3310Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-02-0384
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Funding
- NATIONAL CANCER INSTITUTE [R01CA078846] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039416] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA78846] Funding Source: Medline
- NIAID NIH HHS [AI39416] Funding Source: Medline
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Distinct human dendritic cell (DC) subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that nonobese diabetic/LtSz-scid/scid (NOD/SCID) mice engrafted with human CD34(+) hematopoietic progenitors develop human myeloid and plasmacytoid DCs. The skin displays immature DCs expressing Langerin, while other tissues display interstitial DCs. Myeloid DCs from these mice induce proliferation of allogeneic CD4 T cells in vitro, and bone marrow human cells containing plasmacytoid DCs release interferon-alpha (IFN-alpha) upon influenza virus exposure. Injection of influenza virus into reconstituted mice triggers IFN-alpha release and maturation of mDCs. Thus, these mice may provide a model to study the pathophysiology of human DC subsets. (C) 2003 by The American Society of Hematology.
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