Journal
CELL CYCLE
Volume 10, Issue 11, Pages 1757-1763Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.11.15818
Keywords
Fanconi anemia; DNA repair; ubiquitin; FANCP/SLX4; DNA interstrand crosslink repair
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Funding
- NHLBI NIH HHS [R01 HL101977] Funding Source: Medline
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Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.
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