Journal
CELL CYCLE
Volume 10, Issue 16, Pages 2647-2657Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.10.16.17194
Keywords
EGFR; HER4; isoforms; alternative splicing; cancer; non-neoplastic diseases
Categories
Funding
- Academy of Finland
- Finnish Cancer Organizations
- Foundation for the Finnish Cancer Institute
- Sigrid Juselius Foundation
- Turku University Foundation
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Alternative splicing is a central tool of evolution that significantly increases the size of transcriptomes and generates functional specification. Within the human ERBB receptor gene family, only ERBB4 is known to produce functionally distinct isoforms as a result of alternative splicing. While ErbB4 signaling has been demonstrated to regulate cellular processes involved in embryogenesis, carcinogenesis, and cardiovascular and psychiatric diseases, relatively little is known about the contribution of the individual isoforms in the different biological contexts. Here we review recent findings as well as provide novel data about the distribution and functions of the ERBB4 splice variants. These observations represent an example of how minor alterations in the transcripts of a single gene can result in even antagonistic cellular responses. The observations also underline the significance of understanding the unique functions of isoforms of a potential drug target gene.
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