Journal
CELL CYCLE
Volume 10, Issue 21, Pages 3636-3644Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.10.21.18094
Keywords
genetics; molecular biology; DNA ligases; genome integrity; DNA repair
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Funding
- National Institutes of Health [GM54668]
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DNA ligases are crucial for most DNA transactions, including DNA replication, repair and recombination. Recently, DNA ligase III (Lig3) has been demonstrated to be crucial for cell survival due to its catalytic function in mitochondria. This review summarizes these recent results and reports on a hitherto unappreciated widespread phylogenetic presence of Lig3 in eukaryotes, including in some organisms before the divergence of meta-zoa. Analysis of these putative Lig3 homologs suggests that many of them are likely to be found in mitochondria and to be critical for mitochondrial function.
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