Journal
CELL CYCLE
Volume 10, Issue 13, Pages 2069-2076Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.13.16245
Keywords
negative feedback; signal transduction; quantitative modeling; mitogen activated protein kinase; spatiotemporal dynamics
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Funding
- Science Foundation Ireland [06/CE/B1129]
- Marie Curie International Incoming Fellowship [236758]
- EMBO [ALTF 815-2010]
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Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues(1) presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases as cancer.
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