Related references
Note: Only part of the references are listed.AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer
D. Grahame Hardie
BIOCHEMICAL SOCIETY TRANSACTIONS (2011)
Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy
Kathryn N. Phoenix et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
Mahvash Zakikhani et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Diabetes and Cancer: A Consensus Report
Edward Giovannucci et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2010)
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
Adem Kalender et al.
CELL METABOLISM (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ER alpha negative MDA-MB-435 breast cancer model
Kathryn N. Phoenix et al.
BREAST CANCER RESEARCH AND TREATMENT (2009)
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
John M. L. Ebos et al.
CANCER CELL (2009)
Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
Marta Paez-Ribes et al.
CANCER CELL (2009)
Hypoxia Regulates Insulin Receptor Substrate-2 Expression to Promote Breast Carcinoma Cell Survival and Invasion
Katerina Mardilovich et al.
CANCER RESEARCH (2009)
Expression and function of the insulin receptor substrate proteins in cancer
Katerina Mardilovich et al.
CELL COMMUNICATION AND SIGNALING (2009)
Insulin Receptor Substrate-2 Regulates Aerobic Glycolysis in Mouse Mammary Tumor Cells via Glucose Transporter 1
Shannon L. Pankratz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Is Akt the Warburg kinase?-Akt-energy metabolism interactions and oncogenesis
R. Brooks Robey et al.
SEMINARS IN CANCER BIOLOGY (2009)
Insulin action on glucose transporters through molecular switches, tracks and tethers
Hilal Zaid et al.
BIOCHEMICAL JOURNAL (2008)
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2
Jinhua Wu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Insulin and insulin-like growth factor signalling in neoplasia
Michael Pollak
NATURE REVIEWS CANCER (2008)
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
Jiandi Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
Shannon L. Gibson et al.
CELL CYCLE (2007)
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis
Zhefu Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
Robert K. Dearth et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Hypoxia signalling in cancer and approaches to enforce tumour regression
Jacques Pouyssegur et al.
NATURE (2006)
FoxO1 regulates multiple metabolic pathways in the liver - Effects on gluconeogenic, glycolytic, and lipogenic gene expression
WW Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase α-subunits in heart via hierarchical phosphorylation of Ser485/491
S Horman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
XC Dong et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
BD Manning et al.
GENES & DEVELOPMENT (2005)
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
VN Anisimov et al.
EXPERIMENTAL GERONTOLOGY (2005)
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
ML Macheda et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells
XJ Yi et al.
JOURNAL OF NEUROSCIENCE (2005)
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
P Gual et al.
BIOCHIMIE (2005)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
CURRENT BIOLOGY (2004)
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
LS Harrington et al.
JOURNAL OF CELL BIOLOGY (2004)
Involvement of insulin receptor substrate 2 in mammary tumor metastasis
JA Nagle et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Why do cancers have high aerobic glycolysis?
RA Gatenby et al.
NATURE REVIEWS CANCER (2004)
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
Christina Kaiser et al.
BMC BIOLOGY (2004)
The mammalian SIR2 alpha protein has a role in embryogenesis and gametogenesis
MW McBurney et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Clinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma
SS Kang et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2002)
IRS proteins and the common path to diabetes
MF White
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
A method to identify serine kinase substrates - Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
S Kane et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the α6β4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion
LM Shaw
MOLECULAR AND CELLULAR BIOLOGY (2001)
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
TN Seagroves et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Regulation of glut1 mRNA by hypoxia-inducible factor-1 -: Interaction between H-ras and hypoxia
CH Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
IRS-2 pathways integrate female reproduction and energy homeostasis
DJ Burks et al.
NATURE (2000)
Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
RC Osthus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)