Journal
CELL CYCLE
Volume 10, Issue 21, Pages 3678-3683Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.10.21.18202
Keywords
Morgana; Melusin; ROCK; ERK1/2; genomic stability; centrosome duplication; heart hypertrophy
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Funding
- EUGeneHeart [LSHM-CT-2005-018833]
- Regione Piemonte POR F.E.S.R.
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Chaperones and scaffold proteins are key elements involved in controlling the assembly of molecular complexes required for coordinated signal transduction. Here we describe morgana and melusin, two phylogenetically conserved chaperones that cooperate with Hsp90 and regulate signal transduction in important physiopathological processes. While morgana is ubiquitously expressed, melusin expression is restricted to striated muscles. Despite high sequence homology, the two chaperones have distinct functions. Morgana controls genomic stability by regulating the centrosome cycle via ROCKII kinase. Melusin, on the other hand, organizes ERK signal transduction in cardiomyocytes and regulates cardiac compensatory hypertrophy in response to different stress stimuli.
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