Journal
CELL CYCLE
Volume 9, Issue 18, Pages 3687-3699Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.18.13203
Keywords
RNA polymerase III; cell growth; cell cycle; differentiation; embryonic carinoma cell; embryonic stem cell; cell transformation
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Funding
- Conseil Regional d'Aquitaine
- European Regional Development Fund
- Agence Nationale de la Recherche (ANR)
- Ligue Contre le Cancer-Comites Gironde and Dordogne
- National Institutes of Health [CA113872, DK071900]
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RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular functions in regulating transcription, RNA processing, translation and protein translocation. RNA polymerase III transcription activity is tightly regulated during the cell cycle and coupled to growth control mechanisms. Furthermore, there are reports of changes in RNA polymerase III transcription activity during cellular differentiation, including the discovery of a novel isoform of human RNA polymerase III that has been shown to be specifically expressed in undifferentiated human H1 embryonic stem cells. Here, we review major regulatory mechanisms of RNA polymerase III transcription during the cell cycle, cell growth and cell differentiation.
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