Journal
CELL CYCLE
Volume 9, Issue 5, Pages 953-957Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.5.10876
Keywords
mTOR; rDNA; Pol I; Pol III; tRNA
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Funding
- NIH [R01 CA123391]
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Target of rapamycin (TOR) is a conserved regulator of gene expression from yeast to humans. In budding yeast, TO R is associated with ribosomal DNA (rDNA) promoter, which is critical for ribosome biogenesis and transfer RNA (tRNA) synthesis. Whether mTOR behaves similarly in mammalian cells is unknown. Here, we report that mTOR is detected at several different promoters in human and murine cells, including that of rDNA and tRNA genes. The association of mTOR with these promoters is regulated by growth signals and sensitive to rapamycin. Together, our observations suggest that mTOR is closely involved in gene regulation at the promoters, which is a conserved mechanism to control RNA polymerase I- and III-dependent genes that are critical for protein synthesis and cell growth.
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