Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 18, Issue 11, Pages 1921-1931Publisher
WILEY
DOI: 10.1359/jbmr.2003.18.11.1921
Keywords
menopause; osteoporosis; mechanical loading; growth and development; estrogens
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The primary function of the skeleton is locomotion, and the primary function of estrogen is reproduction. When the skeleton is considered within this locomotive context, the onset of estrogen secretion at puberty leads to packing of mechanically excess mineral into female bones for reproductive needs. Accordingly, the unpacking of this reproductive safety deposit at menopause denotes the origin of type I osteoporosis.
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