Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts: Phorbol myristate acetate induces cell acidosis and the channel activation

The voltage-gated H+ channel is a powerful H+ extruding mechanism of osteoclasts, but its functional roles and regulatory mechanisms remain unclear. Electrophysiological recordings revealed that the H+ channel operated on activation of protein kinase C together with cell acidosis.