Journal
CELL CYCLE
Volume 9, Issue 19, Pages 4005-4012Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.19.13299
Keywords
p53; DNA damage; ribosomal stress; nucleolus; ribosome
Categories
Funding
- MICINN [SAF2009-09343]
- CNIO
- Spanish Ministry of Science
- Regional Government of Madrid
- European Union
- European Research Council (ERC)
- Marcelino Botin Foundation
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Perturbation of ribosomal biogenesis has recently emerged as a relevant p53-activating pathway. This pathway can be initiated by depletion of certain ribosomal proteins, which is followed by the binding and inhibition of MDM2 by a different subset of ribosomal proteins that includes L11. Here, we report that depletion of L37 leads to cell cycle arrest in a L11- and p53-dependent manner. DNA damage can initiate ribosomal stress, although little is known about the mechanisms involved. We have found that some genotoxic insults, namely, UV light and cisplatin, lead to proteasomal degradation of L37 in the nucleoplasm and to the ensuing L11- dependent stabilization of p53. Moreover, ectopic L37 overexpression can attenuate the DNA damage response mediated by p53. These results support the concept that DNA damage-induced proteasomal degradation of L37 constitutes a mechanistic link between DNA damage and the ribosomal stress pathway, and is a relevant contributing signaling pathway for the activation of p53 in response to DNA damage.
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