Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 18, Issue 11, Pages 1995-2001Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/jbmr.2003.18.11.1995
Keywords
tumor necrosis factor; polymorphism; total hip arthroplasty; osteolysis; cytokines; polymorphisms; implants; association; population studies
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Genetic factors may influence implant failure caused by osteolysis after THA. In an association study of 481 subjects after THA, we found that carriage of the TNF-238A allele was associated with an increased incidence of osteolysis versus noncarriage (odds ratio, 1.7) and was independent of other risk factors. Genetic and environmental factors influence implant survival after THA.
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