Journal
CELL CYCLE
Volume 9, Issue 15, Pages 2940-2945Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.15.12335
Keywords
caspase-activated DNase; inhibitor of caspase-activated DNase; non-apoptotic caspase activity; genome reprogramming; epigenetics; gene regulation
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Funding
- Ontario Ministry of Research
- Innovation Ontario Research Fund
- Canadian Institutes of Health Research
- Muscular Dystrophy Association
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In a series of discoveries over the preceding decade, a number of laboratories have unequivocally established that apoptotic proteins and pathways are well conserved cell fate determinants, which act independent of a cell death response. Within this context, the role for apoptotic proteins in the induction of cell differentiation has been widely documented. Despite these discoveries, little information has been forthcoming regarding a conserved mechanism by which apoptotic proteins achieve this non-death outcome. In the following discussion, we will explore the premise that the penultimate step in apoptosis, genome wide DNA damage/strand breaks act as a conserved genomic reprogramming event necessary for cell differentiation (Larsen et al. Proc Natl Acad Sci USA 2010; 107:4230-5). Moreover, we hypothesis that directed DNA damage, as mediated by known apoptotic proteins, may participate in numerous forms of regulated gene expression.
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