Journal
CELL CYCLE
Volume 9, Issue 13, Pages 2657-2662Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.13.12146
Keywords
meiosis; chromosome segregation; cohesin; casein kinase; fission yeast
Categories
Funding
- Austrian Science Fund [P18955, P20444, F3403]
- European Community [FP7/2007-2013, PIEF-GA-2008-220518]
- Austrian Proteomics Platform (APP)
- University of Vienna
- Austrian Science Fund (FWF) [P18955, P20444] Funding Source: Austrian Science Fund (FWF)
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Segregation of chromosomes during meiosis depends on separase cleavage of Rec8, the meiosis-specific alpha-kleisin subunit of cohesin. We mapped Rec8 phosphorylation sites by mass spectrometry and show that, in fission yeast, Rec8 phosphorylation is required for proper chromosome disjunction during meiosis. We further show that the fission yeast casein kinase 1 (CK1) delta/epsilon isoforms Hhp1 and Hhp2 are required for full levels of Rec8 phosphorylation and for efficient removal of Rec8 at the onset of anaphase I. Our data are consistent with the model that Hhp1/Hhp2-dependent phosphorylation of Rec8 is required for separase-mediated cleavage of Rec8 during meiosis I.
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