Journal
CELL CYCLE
Volume 8, Issue 19, Pages 3107-3111Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.19.9590
Keywords
inflammation; epithelial ovarian cancer; fallopian tube; tumor microenvironment; cellular senescence
Categories
Funding
- NIH/NCI [5R01CA1331183]
- University of Texas
- Ovarian Cancer Research Fund
- NATIONAL CANCER INSTITUTE [R01CA013311, R01CA131183] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Epithelial ovarian cancer is a highly lethal gynecological cancer for which overall prognosis has remained poor over the past few decades. A number of theories have been postulated in an effort to explain the etiology of epithelial ovarian cancer, each of which has been both applauded and doubted. Of note, these theories likely are not mutually exclusive, as they all converge more or less on the role of inflammation in promoting ovarian tumorigenesis. In this review, we describe the latest studies on the role of inflammation in the initiation and progression of epithelian ovarian cancer from three major aspects: physiological functions of a normal ovary, potential involvement of the fallopian tube in the initiation of epithelian ovarian cancer and the strong impact of the cellular microenvironment on the development of the disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available