Journal
CELL CYCLE
Volume 8, Issue 20, Pages 3267-3273Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.20.9699
Keywords
inflammation; epithelial-mesenchymal transition; metastasis
Categories
Funding
- NIH [RO1CA125454]
- Susan G. Komen Foundation [KG081310]
- Mary Kay Ash Foundation
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It has been increasingly recognized that tumor microenvironment plays an important role in carcinogenesis. Inflammatory component is present and contributes to tumor proliferation, angiogenesis, metastasis and resistance to hormonal and chemotherapy. This review highlights the role of inflammation in the tumor metastasis. We focus on the function of proinflammatory factors, particularly cytokines during tumor metastasis. Understanding of the mechanisms by which inflammation contributes to metastasis will lead to innovative approach for treating cancer.
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