Journal
CELL CYCLE
Volume 8, Issue 5, Pages 773-779Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.5.7880
Keywords
OCA-S; NAD(+)/NADH redox status; histone expression; mammalian metabolic cycle; S-phase progression
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Funding
- NCI NIH HHS [K23 CA148964] Funding Source: Medline
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Many biological activities naturally oscillate. Here, we show that the NAD(+)/NADH ratios (redox status) fluctuate during mammalian cell cycle, with the S-phase redox status being the least oxidative. The S-phase NAD(+)/NADH redox status gates histone expression and S-phase progression, and may provide a genome protection mechanism during S-phase DNA replication as implicated in yeast. Accordingly, perturbing the cellular redox inhibits histone expression and leads to S-phase arrest. We propose that the S-phase NAD(+)/NADH redox status constitutes a redox signaling, which along with the cyclin E/cdk2 signaling regulates histone expression and S-phase progression.
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