Journal
CELL CYCLE
Volume 8, Issue 11, Pages 1733-1737Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.11.8617
Keywords
aurora-A kinase; microtubule dynamics; interphase; inhibitors
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Funding
- C.N.R.S
- l'Universite Paul Sabatier
- la Region Midi-Pyrenees
- le Canceropole Grand-Sud-Ouest
- la Ligue Nationale Contre le Cancer
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Aurora kinases are key cell cycle regulators and represent attractive new targets in cancer therapy. In this work we investigated the effect of specific inhibition of Aurora-A and Aurora-B on interphase microtubule dynamics using the GSK6000063A and AZD1152 HQPA compounds respectively. We show that Aurora-A inhibition results in microtubule network disorganization and bundling. Using video microscopy and laser-based photo ablation we demonstrate that Aurora-A inhibition decreases microtubule shrinkage, growth rate, frequency rescue and nucleation. These results open new perspectives on the role of Aurora-A in interphase and might be worth considering in a pharmacological perspective.
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