Journal
JOURNAL OF IMMUNOLOGY
Volume 171, Issue 9, Pages 4493-4503Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.171.9.4493
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K22AI001756] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067143] Funding Source: NIH RePORTER
- NIAID NIH HHS [K22 AI001756] Funding Source: Medline
- NIGMS NIH HHS [R01 GM067143, GM67143] Funding Source: Medline
- PHS HHS [T32A1007273, T32A1007001] Funding Source: Medline
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CD8 engagement is believed to be a critical event in the activation of naive T cells. In this communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the necessity of CD8 engagement in T cell activation of primary naive cells. Using two peptides with different measured avidities for the same pMHC-TCR complex, we compared biochemical affinity of pMHC/TCR and the cell surface binding avidity of pMHC/TCR with and without CD8 engagement. We compared early signaling events and later functional activity of naive T cells in the same manner. Although early signaling events are altered, we find that high-affinity pMHC/TCR interactions can overcome the need for CD8 engagement for proliferation and CTL function. An integrated signal over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement.
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