Journal
CELL CYCLE
Volume 8, Issue 20, Pages 3262-3266Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.20.9690
Keywords
taxol; paclitaxel; chromosomal instability; spindle; segregation errors; aneuploidy; mitosis; centrosome
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Funding
- Cancer Research UK
- Medical Research Council
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Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.
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