Journal
CELL CYCLE
Volume 8, Issue 10, Pages 1473-1477Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.10.8349
Keywords
miR-122; HCV; translation; activation; regulation
Categories
Funding
- Deutsche Forschungsgemeinschaft, DFG [SFB 535, IRTG 1384, Ni 604/1-1, Ni 604/2-1]
- Universitatsklinikum Giessen und Marburg GmbH
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microRNAs (miRNAs) are involved in the regulation of translation of many mRNAs and affect cell cycle progression, differentiation and metabolism. The liver-specific microRNA-122 (miR-122) contributes to the liver tropism of Hepatitis C Virus (HCV) by accelerating the binding of ribosomes to the viral RNA and thereby stimulating HCV translation. Here, the most recent results on the molecular mechanisms of microRNA action on HCV and the implications for the understanding of translation regulation by microRNAs are discussed.
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