Journal
NUCLEIC ACIDS RESEARCH
Volume 31, Issue 21, Pages 6064-6078Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkg815
Keywords
-
Categories
Ask authors/readers for more resources
Designer molecules that can specifically target pre-determined DNA sequences provide a means to modulate endogenous gene function. Different classes of sequence-specific DNA-binding agents have been developed, including triplex-forming molecules, synthetic polyamides and designer zinc finger proteins. These different types of designer molecules with their different principles of engineered sequence specificity are reviewed in this paper. Furthermore, we explore and discuss the potential of these molecules as therapeutic modulators of endogenous gene function, focusing on modulation by stable gene modification and by regulation of gene transcription.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available