Journal
BIOLOGY OF REPRODUCTION
Volume 69, Issue 5, Pages 1449-1457Publisher
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.103.019364
Keywords
behavior; hypothalamus; neuroendocrinology; steroid hormone receptors
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Funding
- NIDDK NIH HHS [R01 DK061935-02, R01 DK61935, R01 DK061935] Funding Source: Medline
- NIMH NIH HHS [R01 MH047538] Funding Source: Medline
- PHS HHS [T32 MG47538] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK061935] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH047538] Funding Source: NIH RePORTER
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Gonadal steroid hormones act throughout the body to elicit changes in gene expression that result in profound effects on reproductive physiology and behavior. Steroid hormones exert many of these effects by binding to their respective intracellular receptors, which are members of a nuclear receptor superfamily of transcriptional activators. A variety of in vitro studies indicate that nuclear receptor coactivators are required for efficient transcriptional activity of steroid receptors. Many of these coactivators are found in a variety of steroid hormone-responsive reproductive tissues, including the reproductive tract, mammary gland, and brain. While many nuclear receptor coactivators have been investigated in vitro, we are only now beginning to understand their function in reproductive physiology and behavior. In this review, we discuss the general mechanisms of action of nuclear receptor coactivators in steroid-dependent gene transcription. We then review some recent and exciting findings on the function of nuclear receptor coactivators in steroid-dependent brain development and reproductive physiology and behavior.
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