Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 22, Pages 12373-12377Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.22.12373-12377.2003
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052774] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI052774, R01 AI52774] Funding Source: Medline
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Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans-complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 sequences to mediate the formation of infectious extracellular HIV-1 virions. These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6.
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