Journal
STROKE
Volume 34, Issue 12, Pages 2995-2998Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.STR.0000098902.69855.A9
Keywords
brain imaging; classification; diagnosis
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [Z01NS002975] Funding Source: NIH RePORTER
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Background-Existing diagnostic classification systems for cerebrovascular disease are based primarily on clinical impression of temporal features, clinical syndrome, inferred localization, or ischemic mechanism. Diagnostic certainty of the ischemic pathology based on supportive or refuting laboratory or radiological evidence has been of secondary importance. Summary of Comment-Acute ischemic cerebrovascular syndrome (AICS) describes a spectrum of clinical presentations that share a similar underlying pathophysiology: cerebral ischemia. Diagnostic criteria for AICS incorporate prior classification systems and currently available information provided by neuroimaging and laboratory data to define 4 categories ranging from definite AICS to not AICS, which define the degree of diagnostic certainty. Conclusions-Clinical trials testing new treatments for acute ischemic stroke or secondary stroke prevention should limit enrollment to patients with definite AICS whenever feasible.
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