Journal
CELL CYCLE
Volume 8, Issue 9, Pages 1324-1328Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.9.8253
Keywords
miRNA; cholangiociliopathies; miR-15a; Cdc25A; cholangiocyte; proliferation
Categories
Funding
- NIDDK NIH HHS [P30 DK084567, R01 DK024031] Funding Source: Medline
Ask authors/readers for more resources
This review is focused on current findings implicating miRNAs in the polycystic liver diseases, which we categorized as cholangiociliopathies. Our recent data suggest that deregulation of miRNA pathways is emerging as a novel mechanism in the development of cholangiociliopathies. Experimental evidence demonstrates that miRNAs (i.e., miR-15a) influence hepatic cyst growth by affecting the expression of the cell cycle regulator, Cdc25A. Given that abnormalities in many cellular processes (i.e., cell cycle regulation, cell proliferation, cAMP and calcium signaling, the EGF-stimulated mitogen-activated protein kinase (MAPK) pathway and fluid secretion) contribute to the hepatic cystogenesis, the potential role of miRNAs in regulation of these processes is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available