Journal
SCHIZOPHRENIA RESEARCH
Volume 65, Issue 1, Pages 27-32Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0920-9964(02)00531-5
Keywords
association study; clozapine; polymorphism; psychopathology; schizophrenia; tumor necrosis factor alpha
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Tumor necrosis factor alpha (TNF-alpha), a potent immunomodulator and proinflammatory cytokine, has been implicated in schizophrenia pathogenesis and clozapine response. Two studies have established an association between schizophrenia and the TNF-alpha gene -308G/A polymorphism; however, both increased and decreased - 308A allele frequency have been reported in two analogous investigations. The present study examined the hypothesis that the TNF-alpha gene - 308G/A polymorphism confers susceptibility to schizophrenia in 205 patients with schizophrenia compared with 192 controls. A subgroup of 99 clozapine-treated schizophrenia patients was also tested for the genetic effects of this polymorphism, as evidenced by clinical manifestation, and clozapine-related therapeutic outcome and body-weight change. The results of these investigations suggest that the TNF-alpha gene - 308G/A variants do not play a major role in susceptibility to, clinical manifestations for, or clozapine response in, schizophrenia. (C) 2003 Elsevier Science B.V. All rights reserved.
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