Journal
ATHEROSCLEROSIS SUPPLEMENTS
Volume 4, Issue 4, Pages 33-40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S1567-5688(03)00032-1
Keywords
asymmetric dimethylarginine; nitric oxide; dimethylarginine dimethylaminohydrolase; cardiovascular disease
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An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS), particularly asymmetric dimethylarginine (ADMA) regulate nitric oxide generation in numerous disease states. Two dimethylarginine dimethylaminobydrolase (DDAH) enzymes metabolise ADMA. We and others have postulated that activity of DDAH is a key determinant of ADMA levels in vivo. This review summarises recent advances in the regulation and function of DDAH enzymes and its role in the regulation of nitric oxide generation. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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