Assisted reproduction in patients with early-stage ovarian malignancies

Objective: To determine the outcome of women with early-stage ovarian malignancies who subsequently underwent assisted reproductive technologies (ART). Design: Retrospective study. Setting: Academic assisted reproductive technology program. Patient(s): Four infertile women who were previously diagnosed with early-stage ovarian malignancies. Intervention(s): Controlled ovulation hyperstimulation, IVF, and/or gamete intrafallopian transfer treatments using clomiphene citrate and/or gonadotropins. Main Outcome Measure(s): Development of tumor recurrence and disease-free interval. Result(s): All four women remain free of disease for up to 15 years after treatment. Three of the four women achieved pregnancy. Conclusion(s): In patients with early-stage ovarian malignancies, conservative therapy followed by ovarian stimulation for assisted reproduction is an acceptable strategy. (Fertil Steril(R) 2003;80:1510-12. (C) 2003 by American Society for Reproductive Medicine.).