Journal
CELL CYCLE
Volume 8, Issue 2, Pages 236-238Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.8.2.7413
Keywords
angiogenesis; tumor; endothelial cell; cancer; progenitor cell; stem cell
Categories
Funding
- NIH [CA37392, CA45548]
- Leonora DeBella
- the American Cancer Society
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We recently reported that prostate tumor-specific endothelial cells had features of mesenchymal stem cells and could trans-differentiate to form cartilage and bone-like tissues. Plasticity in the tumor vasculature may be related to well-known tumor blood vessel abnormalities and could underlie an intrinsic adaptive mechanism in tumor endothelial cells for circumventing anti-angiogenic strategies.
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