Journal
CELL CYCLE
Volume 8, Issue 22, Pages 3777-3781Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.22.10121
Keywords
senescence; p53; p21; quiescence; cell cycle
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Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in HT1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).
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