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Antioxidant defense and aging in C. elegans Is the oxidative damage theory of aging wrong?

Journal

CELL CYCLE
Volume 8, Issue 11, Pages 1681-1687

Publisher

TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.11.8595

Keywords

aging; antioxidant; C. elegans; catalase; free radical; nematode; oxidative stress; ROS; superoxide dismutase; theory

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Funding

  1. European Union
  2. Wellcome Trust

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The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?

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