Journal
CELL CYCLE
Volume 7, Issue 17, Pages 2643-2646Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.17.6597
Keywords
microRNA; non-coding RNA; gene expression; cancer
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Funding
- OCRF (GC and LZ), NCI [SPORE P01-CA83638]
- American Cancer Society [IRG-78002-30]
- Mary Kay Ash Charitable Foundation (LZ)
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microRNAs (miRNAs) are an abundant class of small non-coding RNAs that function as gene regulators. Although deregulation of miRNA expression is involved in the initiation and progression of tumorigenesis, the underlying mechanisms of miRNA deregulation in human cancer are still largely unknown. Increasing evidence indicates that transcriptional deregulations, epigenetic alterations, mutations, DNA copy number abnormalities and defects in the miRNA biogenesis machinery might contribute to miRNA deregulation in human cancer. A clearer understanding of the mechanisms involved in miRNA deregulation in human cancer will contribute greatly to the development of new miRNA-based strategies in cancer diagnosis and treatment.
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