Journal
CELL CYCLE
Volume 7, Issue 6, Pages 725-728Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.6.5573
Keywords
oct-4; oct3/4; embryonic stem cells; cancer; multipotent stem cells; mesenchymal stem cell; bone marrow; ES cells
Categories
Ask authors/readers for more resources
Since its discovery as a critical regulator of pluripotency in embryonic stem ( ES) cells and the inner cell mass of the developing blastocyst, the Pou domain-containing transcription factor Oct4 has become a proxy for stemness in numerous studies of somatic stem cells as its presence is often taken as evidence of pluripotency in these cells. Recent studies, however, have demonstrated that not only is Oct4 dispensable for maintaining potency in somatic stem cell compartments, but also that the methods applied to detect Oct4 and the interpretation of the resulting data may be flawed. Here we contrast pathways known to govern pluripotency in embryonic stem cells with those in adult stem cells and critically discuss the concept of pluripotency in adult stem cells of the mammalian soma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available