Journal
CELL CYCLE
Volume 7, Issue 17, Pages 2621-2625Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.7.17.6514
Keywords
PI3-kinase; Akt; GSK-3; microtubule; mitosis; centrosome
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/B/08019] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/B/08019] Funding Source: researchfish
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Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.
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