4.7 Article

Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 17, Pages 2162-2163

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b306867f

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Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.

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