Journal
CELL CYCLE
Volume 7, Issue 22, Pages 3509-3513Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.22.6978
Keywords
cell cycle machinery; spermatogenesis; germ cell differentiation; meiosis; male germ cell stem cells; mitosis; cyclin-dependent kinases; apoptosis
Categories
Funding
- NIH [HD034915]
- Indo-US Program on Contraception and Reproductive Health
Ask authors/readers for more resources
The specialized cell cycles that characterize various aspects of the differentiation of germ cells provide a unique opportunity to understand heretofore elusive aspects of the in vivo function of cell cycle regulators. Key components of the cell cycle machinery are the regulatory sub-units, the cyclins, and their catalytic partners, the cyclin-dependent kinases. Some of the cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions, predictions that are being explored by targeted mutagenesis in mouse models. A novel, meiosis-specific function has been shown for one of the A-type cyclins, cyclin A1. Embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1, while yet other cyclins, although expressed at specific stages of germ cell development, may have less essential function in the male germline.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available