Journal
CELL CYCLE
Volume 7, Issue 3, Pages 304-308Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.3.5360
Keywords
calcium homeostasis; apoptosis; ROS; cell death; Pin1; PKC
Categories
Funding
- NIA NIH HHS [P01 AG025532-020002] Funding Source: Medline
- Telethon [GGP05284] Funding Source: Medline
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- Fondazione Telethon Funding Source: Custom
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The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its proapoptotic activity upon oxidative stress. This model, that could explain the alterations of mitochondrial Ca2+ homeostasis observed after oxidative stress, highlights novel pharmacological targets in age-related disorders.
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