Journal
CELL CYCLE
Volume 7, Issue 22, Pages 3487-3490Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.22.7045
Keywords
Cdk5; p27; E2F1; non-catalytic; cell cycle suppressor
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Funding
- NIA NIH HHS [R01 AG024494] Funding Source: Medline
- NINDS NIH HHS [R01 NS020591-25, R01 NS020591] Funding Source: Medline
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Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk that is primarily active in postmitotic neurons. An important core function of Cdk5 involves regulating the migration and maturation of embryonic post-mitotic neurons. These developmental roles are dependent on its kinase activity. Initially, there was little evidence indicating a role for Cdk5 in normal cell cycle regulation. Recent data from our lab, however, suggest that Cdk5 plays a crucial role as a cell cycle suppressor in normal post-mitotic neurons and neuronal cell lines. It performs this foundation in a kinase independent manner. Cdk5 normally found in both nucleus and cytoplasm, but it exits the nucleus in neurons risk to death in an AD patient's brain. The shift in sub-cellular location is accompanied by cell cycle re-entry and neuronal death. This new function of Cdk5 raises cautions in the design of Cdk5-directed drugs for the therapy of neurodegenerative diseases.
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