Journal
CELL CYCLE
Volume 7, Issue 16, Pages 2493-2499Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.16.6452
Keywords
microRNA; oncogene; tumor suppressor; c-Myc; p53; nuclear factor kappa B; fusion oncoprotein; gene expression
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Funding
- National Institutes of Health [R01 CA120185]
- Sol Goldman Pancreatic Cancer Research Center
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A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.
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