Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 1, Pages 726-731Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.1.726-731.2003
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Funding
- NHLBI NIH HHS [HL54785, P50 HL054785] Funding Source: Medline
- NIAID NIH HHS [AI28691, P30 AI028691] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL054785] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI028691] Funding Source: NIH RePORTER
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The cells of most Old World monkey species exhibit early, postentry restrictions on infection by human immunodeficiency virus type 1 (HIV-1) but not by simian immunodeficiency virus of macaques (SIVmac). Conversely, SIVmac but not HIV-1, infection is blocked in most New World monkey cells. By using chimeric HIV-I/SIVmac viruses capable of a single round of infection, we demonstrated that a major viral determinant of this restriction is the capsid (CA) protein. The efficiency of early events following HIV-1 and SIVmac entry is apparently determined by the interaction of the incoming viral CA and species-specific host factors.
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