Journal
CELL COMMUNICATION AND SIGNALING
Volume 9, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1478-811X-9-19
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Funding
- Ministry of Science and Higher Education, Poland [N301 092 32/3407, N407 075 137]
- Polish Mitochondrial Network
- Italian Association for Cancer Research (AIRC), Telethon [GGP09128]
- University of Ferrara
- Italian Ministry of Education, University and Research (COFIN)
- Italian Cystic Fibrosis Research Foundation
- Italian Ministry of Health
- FIRC
- FISM - Fondazione Italiana Sclerosi Multipla [Cod. 2010/B/1, Cod. 2010/B/13]
- Foundation for Polish Science (FNP)
- UE
- European Regional Development Fund
- Operational Programme Innovative economy
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Calcium (Ca2+) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca2+ concentration is dependent either on Ca2+ influx from the extracellular space through the plasma membrane, or on Ca2+ release from intracellular Ca2+ stores, such as the endoplasmic/sarcoplasmic reticulum (ER/SR). Mitochondria are also major components of calcium signalling, capable of modulating both the amplitude and the spatio-temporal patterns of Ca2+ signals. Recent studies revealed zones of close contact between the ER and mitochondria called MAMs (Mitochondria Associated Membranes) crucial for a correct communication between the two organelles, including the selective transmission of physiological and pathological Ca2+ signals from the ER to mitochondria. In this review, we summarize the most up-to-date findings on the modulation of intracellular Ca2+ release and Ca2+ uptake mechanisms. We also explore the tight interplay between ER-and mitochondria-mediated Ca2+ signalling, covering the structural and molecular properties of the zones of close contact between these two networks.
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