Journal
CELL COMMUNICATION AND ADHESION
Volume 17, Issue 4-6, Pages 83-92Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/15419061.2010.551682
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Funding
- National Nature Science Foundation of China [30770951]
- China-Russia Cooperation Research Foundation [81011120108]
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Mucus hypersecretion is commonly observed in many chronic airway inflammatory diseases. Mucin 5AC (MUC5AC) is a major airway mucin because of its high expression in goblet cells. Here, the authors identified a gene called SAM domain--containing prostate-derived Ets factor (SPDEF) that was induced by interleukin (IL)-13. Their results showed that specific knockdown of SPDEF reduced IL-13-induced MUC5AC expression in human airway epithelial cells. This finding was associated with decreased expression of anterior gradient 2 (AGR2) and Ca
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