Journal
CELL COMMUNICATION AND ADHESION
Volume 17, Issue 2, Pages 48-54Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/15419061.2010.492535
Keywords
cell-cell contacts; cell shape; differentiation; ECM properties; geometric controls; mechanical force; morphogenic factors
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Funding
- NHLBI NIH HHS [R21 HL094402-02, R21 HL094402, R21 HL094402-01] Funding Source: Medline
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A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.
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