Journal
CLINICAL INFECTIOUS DISEASES
Volume 37, Issue 9, Pages 1244-1249Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/378808
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Funding
- NIAID NIH HHS [P30 AI036211, AI36211] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI036211] Funding Source: NIH RePORTER
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Patients with human immunodeficiency virus type 1 (HIV-1) infection are at high risk of developing Epstein-Barr virus (EBV)-associated lymphoma. However, little is known of the EBV DNA loads in patients receiving highly active antiretroviral therapy (HAART). Using a real-time quantitative polymerase chain reaction assay, we demonstrated that significantly more HIV-1-infected patients receiving HAART than HIV-1-uninfected volunteers had detectable EBV DNA in blood (57 [81%] of 70 vs. 11 [16%] of 68 patients; P = .001) and saliva (55 [79%] of 68 vs. 37 [54%] of 68 patients; P = .002). The mean EBV loads in blood and saliva samples were also higher in HIV-1-infected patients than in HIV-1-uninfected volunteers (P = .001). The frequency of EBV detection in blood was associated with lower CD4(+) cell counts (P = .03) among HIV-1-infected individuals, although no differences were observed in the EBV DNA loads in blood or saliva samples in the HIV-1-infected group. Additional studies are needed to determine whether EBV-specific CD4(+) and CD8(+) cells play a role in the pathogenesis of EBV in HIV-1-infected patients receiving HAART.
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