Journal
CELL CALCIUM
Volume 55, Issue 3, Pages 139-145Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.02.008
Keywords
Mitochondrial Ca2+ uniporter; MCU; MICU1; MICU2; EMRE; MCUR
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Funding
- FIRB from the Italian Ministry of University and Research (MIUR)
- Veneto Region
- National Research Council (CNR)
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The molecular components of the mitochondrial Ca2+ uptake machinery have been only recently identified. In the last months, in addition to the pore forming subunit and of one regulatory protein (named MCU and MICU1, respectively) other four components of this complex have been described. In addition, a MCU KO mouse model has been generated and a genetic human disease due to missense mutation of MICU1 has been discovered. In this contribution, we will first summarize the recent findings, discussing the roles of the different subunits of the mitochondrial Ca2+ uptake complex, pointing to the current contradictions in the published data, as well as possible explanations. Finally we will speculate on the recent, totally unexpected, results obtained in the MCU knock-out (KO) mice. (C) 2014 The Authors. Published by Elsevier Ltd.
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